世界針灸學會聯合會

隔姜灸不同穴位對慢性胃炎作用機制的隱性相關性研究

作者:李璟 來源:世界針灸雜志 點擊:1372次 更新:2019-11-27
  

Jun-wei GU(顧俊薇)a, Xu-ming YANG (楊旭明)b, Qi LI (李琪)a, Mu-en GU (顧沐恩)a, Meng-die WU (吳夢蝶)a, Shu-fei CAO (曹淑菲)c, Jing LI (李璟)a*

aYueyang Integrative Chinese and Western Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China (上海中醫藥大學附屬岳陽中西醫結合醫院 上海 200437, 中國)

bShanghai University of Traditional Chinese Medicine, Shanghai 201023, China (上海中醫藥大學 上海 201023, 中國)

cClinic of Laochenghuangmiao Tonghaichuntang clinic, Shanghai 200010, China (老城隍廟童涵春堂門診部, 上海 200010, 中國)

☆Supported by National Natural Science Foundation of China: 81674071; Shanghai TCM technological innovation program: ZYKC201601002

*Corresponding author

Email address: [email protected] (Jing LI)


ABSTRACT

Objective: To observe the differences in the effects and mechanisms on chronic gastritis treated by  ginger-isolated moxibustion at Zúsānl?  (足三里ST 36) and Nèiguān (內關PC 6).

Methods: A total of 60 eligible patients of chronic gastritis were randomized into two groups, a ST 36 group (ginger-isolated moxibustion at ST 36, 30 cases) and a PC 6 group (ginger-isolated moxibustion at PC 6, 30 cases). Before and after 6 treatments, the total variability of heart rate (TV) and the scores in Scale for gastrointestinal diseases of traditional Chinese medicine were determined and recorded. Using correlation analysis, the hidden correlation condition that affects the therapeutic outcomes was excavated from the data. With least square method, the gradient curve (K value) of TV in treatment was estimated and the correlation between the effect mechanism and autonomic nerve regulation was excavated.

Results: ① In ST 36 group, the duration of sickness, severity of disease and the activity of autonomic nerve before treatment presented the underlying correlation with the therapeutic effects. In contrast, the hidden correlation in PC 6 group was not clear. ② In ST 36 group, the higher  K value of TV in treatment was, the more significant the therapeutic effects were, but in PC group, K value was reversely related to the therapeutic effects.

Conclusion: The therapeutic effects of ginger-isolated moxibustion at single acupoint are correlated with the duration and severity of sickness. The therapeutic effects in ST 36 group were improved by the modulation of autonomic nerve activity and the effects in PC 6 group were negatively correlated with autonomic nerve activity. It is deduced that the effect mechanisms are different on single acupoint for chronic gastritis between the two points.

Keywords: Isolated ginger moxibustion, Chronic gastritis, Data mining, Association algorithm

[摘 要]

目的:觀察隔姜灸對足三里和內關治療慢性胃炎的作用及機制的差異。

方法:將60例符合條件的慢性胃炎患者隨機分為兩組,即足三里組(隔姜灸足三里, 30例)和內關組(隔姜灸內關, 30例)。分別于治療前后測定心率總變異性(TV)及胃腸道疾病量表評分。通過相關分析,從數據中挖掘出影響治療效果的隱性相關條件。用最小二乘法估計治療中TV的梯度曲線(K值),挖掘其作用機制與自主神經調節的相關性。

結果:①足三里組患者的病程、病情嚴重程度、治療前自主神經活動度與治療效果有一定的相關性。與之相反,內關組間的隱性相關不明顯。②足三里組治療中TV的K值越高,療效越顯著,內關組則K值與療效呈負相關。

結論:隔姜灸單穴位的療效與病程及病情嚴重程度有關。足三里組通過調節自主神經活動改善療效,內關組療效與自主神經活動呈負相關。推測慢性胃炎單穴治療的作用機理不同。

[關鍵詞] 隔姜灸,慢性胃炎,數據挖掘,關聯算法

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